Cytochrome P450 Inhibitors And Inducers Table

This is a list of cytochrome p450 modulators or inhibitors and inducers of cytochrome p450 enzymes.

Cytochrome p450 inhibitors and inducers table.

The table contains lists of drugs in columns under the designation of specific cytochrome p450 isoforms. Cytochrome p450 drug interaction table drug interactions. Paroxetine a cytochrome p450 2d6 inhibitor. Substrates inducers and inhibitors of cytochrome p450 preventing drug drug interactions in psychiatry.

Are either potent inhibitors or inducers of cyp450 enzymes. Asenapine chlorpromazine clonidine clozapine duloxetine fluvoxamine lorcaserin loxapine olanzapine paliperidone. Abbreviated clinically relevant table inhibitors a strong inhibitor is one that causes a 5 fold increase in the plasma auc values or more than 80 decrease in clearance. Drug development and drug interactions.

Advisory committee meetings drug interaction presentations. A moderate inhibitor is one that causes a 2 fold increase in the plasma auc values or 50 80 decrease in clearance. Drug interactions are referred to as either inhibitors or inducers table 1 10. P450 drug interaction table.

This table is designed as a hypothesis testing teaching and reference tool for physicians and researchers interested in drug interactions that are the result of competition for or effects on the human cytochrome p450 system.